Type 2 diabetes symptoms can go unnoticed for many years or be mistaken for less serious health conditions. If it goes undetected, serious health complications can occur, such as kidney damage, nerve damage and cardiovascular disease.
One of the most commonly recognized symptoms of type 2 diabetes include feeling thirsty all the time. But another sign of the condition can be evident in the armpit, express.co.uk wrote.
Areas of darkened skin is a notable symptoms, according to Mayo Clinic.
It explained: “Some people with type 2 diabetes have patches of dark, velvety skin in the folds and creases of their bodies.”
This usually occurs in the armpit, and can also appear on the neck.
The condition is known as acanthosis nigricans and may be a sign of insulin resistance.
Other symptoms of type 2 diabetes, the NHS notes, include:
• Feeling thirsty all the time
• Feeling very tired
• Losing weight without trying to
• Cuts or wounds taking longer to heal
• Blurred vision
Other symptoms to note are in a person’s pee. These include going to the toilet a lot, especially at night, having a certain smelling urine, and blood in urine.
Frequent urination is a condition known as polyuria. This is defined as passing more than three liters a day of urine, compared to the normal one or two liters.
While it’s often the result of drinking excessive amounts of fluids, it is also one of the main symptoms of diabetes.
“When the kidneys filter blood to make urine, they reabsorb all of the sugar, returning it to the bloodstream,” explained diabetes.co.uk.
It adds: “In diabetes, the level of sugar in the blood is abnormally high. Not all the sugar can be reabsorbed and some this excess glucose from the blood ends up in the urine where it draws more water.
“This results in unusually large volumes of urine.”
If a person has healthy urine it should not really have a smell, according to the NHS.
It may smell stronger in the morning when it’s more concentrated, or if someone is dehydrated, but other side it should not be noticeable.
But the health body warns if you’re urine is sweet-smelling it could be a sign of diabetes.
If your wee smells more concentrated than normal, it could also be an early warning sign of diabetes, according to Now Patient’s Chief Medical Officer, Dr. Andrew Thornber.
Blood in urine
Kidney disease, also known as diabetic nephropathy, is more common in people with diabetes, and a symptom of kidney disease can be blood appearing in urine.
“Kidney disease is caused by damage to smell vessels. This damage can cause the vessels to become leaky or, in some cases, to stop working, making the kidneys work less efficiently,” said Diabetes UK.
It further explains: “Keeping blood glucose levels as near normal as possible can greatly reduce the risk of kidney disease developing as well as other diabetes complications.
“It is also very important to keep blood pressure controlled.”
Health Problems from Wearing Heels
Heels are one of those great inventions that make anything look fabulous, but is a torture device at the same time. Podiatrist have a distinct hatred for heels and the health problems it brings to the wearer. We wear heels as part of our professional attire or for fashion, but at the end of the day we all slump up on our sofa saying “my feet is killing me”. Who knows why we still allow ourselves to go through this torture, but wearing heels does make you feel a little bit more powerful.
Human feet are not designed to wear heels all the time. Our feet are designed at a 90 degree angle to fully support our frame, altering it to a 60 or 45 degree angle will alter the foot function and position causing health problems. Below are some of the health problems you will encounter from wearing heels overtime.
Heels will increase the pressure on your forefoot and making you adjust your posture to maintain balance. Your lower body will tend to lean forward as your lower body leans backward. Long period of keeping this position will affect the posture.
The back and spine have a normal S- curve that helps absorb shock and lessen pressure on the spine. Wearing heels will flatten this structure and alter the body’s positioning. This poor alignment will cause you to use more muscles, causing muscle pain and back pain. Posterior displacement can be fixed with the help of a medical professional.
Toe Pain and Ankle Pain
Wearing heels will increase the pressure that your toes and ankle face. Trying to balance out your body structure while wearing heels can wear down the joints in your ankles and cause muscles inflammation and calluses on the feet and toes.
Corns and Keratin Build-up
Corns and Keratin build-up will start to appear on the feet due to the pressure on the skin. Corn usually appears under the balls of the foot where most of the weight is pressed down. This corns will feel like small rocks and can cause discomfort.
Pinched nerves or neuromas can cause mild to severe pain to wearers in the future, leaving it untreated can cause severe damage in the future.
Crack on the Bones
Wearing heels for a long period of time will result in cracks in the bones of the feet and stress fractures.
Choose low heels that have a slightly thicker heel. This will allow more balance and spread the pressure on your feet.
Wear soft insoles. Wear rubber soled shoes instead of leather, this will absorb pressure better.
Wear heels when there is limited standing or walking. Bring flat shoes when commuting or walking for a long period of time.
Stretch every day, especially leg and calf stretches in the morning and at night.
Take in calcium supplements to make the bones stronger.
Wear heels are seldom as possible.
Obesity can impair learning, memory: Study
Obesity can break down our protective blood brain barrier resulting in problems with learning and memory, a study has found. Chronic activation of the receptor Adora2a on the endothelial cells that line this important barrier in our brain can let factors from the blood enter the brain and affect the function of our neurons, scientists said.
The team from Augusta University in the US have shown that when they block Adora2a in a model of diet-induced obesity, this important barrier function is maintained. “We know that obesity and insulin resistance break down the blood brain barrier in humans and animal models, but exactly how has remained a mystery,” said Alexis M Stranahan, neuroscientist at Augusta University and corresponding author of the study published in The Journal of Neuroscience.
In the brain, adenosine is a neurotransmitter that helps us sleep and helps regulate our blood pressure; in the body it’s also a component of the cell fuel adenosine triphosphate, or ATP.Adenosine also activates receptors Adora1a and Adora2a on endothelial cells, which normally supports healthy relationships between brain activity and blood flow.
Problems arise with chronic activation, particularly in the brain, which is what happens with obesity, Stranahan said in a statement. People who have obesity and diabetes have higher rates of cognitive impairment as they age and most of the related structural changes are in the hippocampus, a centre of learning and memory.Fat is a source of inflammation and there is evidence that reducing chronic inflammation in the brain helps prevent obesity-related memory loss.
For the study, young mice fed a high-fat diet got fat within two weeks, and by 16 weeks they had increases in fasting glucose and insulin concentrations, all signs that diabetes is in their future. In the minute vasculature of the hippocampus, the researchers saw that obesity first increased permeability of the blood brain barrier to tiny molecules like fluorophore sodium fluorescein, or NaFl. Diet-induced insulin resistance heightened that permeability so that a larger molecule, Evans Blue, which has a high affinity for serum albumin, the most abundant protein in blood, also could get through.
When they looked with electron microscopy, they saw a changed landscape. Resulting diabetes promoted shrinkage of the usually tight junctions between endothelial cells and actual holes in those cells. When they gave a drug to temporarily block Adora2a, it also blocked problems with barrier permeability. Whether that could work in humans and long term as a way to avoid cognitive decline in obese humans, remains to be seen, Stranahan said.
‘Love hormone’ may help treat alcoholism, says study
A nasal spray of ‘love hormone’ oxytocin may help treat alcohol use disorder, according to a study conducted in mice.
Oxytocin plays a role in social bonding, sexual reproduction, childbirth, and the period after childbirth.
The study, published in the journal PLOS Biology, found that oxytocin blocks enhanced drinking in alcohol-dependent rats.
Targeting the oxytocin system may provide novel pharmaceutical interventions for the treatment of alcohol-use disorder, said researchers from the National Institutes of Health and The Scripps Research Institute in the US.
Administering oxytocin can decrease consumption, withdrawal symptoms, and drug-seeking behaviour associated with several drugs of abuse, researchers said in a statement.
This shows promise as a pharmacological approach to treat drug addiction, they said.
Researchers tested the hypothesis that oxytocin administration could normalise the maladaptive brain changes that occur in alcohol dependence and thereby reduce alcohol drinking in an established rat model of alcohol dependence.
They investigated oxytocin’s effects on dependence-induced alcohol consumption and altered signalling of the inhibitory neurotransmitter GABA in the central nucleus of the amygdala (CeA) – a key brain region in the network affected by alcohol dependence.
The experiments demonstrated that oxytocin administered systemically, intranasally or into the brain blocked excess drinking in alcohol-dependent but not in normal rats.
Moreover, oxytocin blocked GABA signalling in the CeA, researchers said.
Taken together, these results provide evidence that oxytocin likely blocks enhanced drinking by altering CeA GABA transmission.
These results provide evidence that aberrations in the oxytocin system may underlie alcohol use disorder, researchers said.
Targeting this system, possibly by intranasal administration, could prove a promising therapy in people who misuse alcohol, they said.