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New ‘Trojan horse’ drug kills cancer from inside

The Kashmir Monitor

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A novel cancer drug which acts as a ‘Trojan horse’ to destroy tumours from the inside has shown promising results across six different forms of the deadly disease, scientists say. In patients with advanced, drug-resistant cancers, over a quarter with cervical and bladder tumours, and nearly 15 per cent with ovarian and lung tumours, responded to the new treatment, said researchers from the Institute of Cancer Research in the UK.

The innovative new drug, called tisotumab vedotin (TV), releases a toxic substance to kill cancer cells from within.

The results, published in The Lancet Oncology, are so positive the drug has now moved forward to phase II trials in cervical cancer and will be tested in a range of additional solid tumour cancers. The researchers led a global clinical trial of nearly 150 patients with a variety of cancer types who had stopped responding to standard treatments. They found that a significant minority of cancer patients responded to the drug, with their tumours either shrinking or stopping growing.

 

The researchers saw responses in 27 per cent of patients with bladder cancer, 26.5 per cent with cervical cancer, 14 per cent ovarian cancer, 13 per cent with oesophageal, 13 per cent with non-small cell lung and seven per cent with endometrial cancer.

Responses lasted an average of 5.7 months, and up to 9.5 months in some patients, researchers said. TV is made up of a toxic drug attached to the tail end of an antibody. It is designed to seek out a receptor called ’tissue factor’ — present at high levels on the surface of many cancer cells and linked with worse survival. Binding to tissue factor draws the drug inside cancer cells, where it can kill them from within.

The trial initially recruited 27 patients to assess safety and establish the right dose, before expanding to a further 120 patients primarily to look at whether the drug was hitting the right target but also at what effect it had on tumours.

The majority of patients in the early trial had advanced stage cancer (spread locally or around the body) that had already been treated with, and became resistant to, an average of three different types of treatment. TV is now being trialled in other cancer types including bowel, pancreatic, squamous cell lung and head and neck, as well as in a phase II trial as a second-line treatment for cervical cancer.

“What is so exciting about this treatment is that its mechanism of action is completely novel — it acts like a Trojan horse to sneak into cancer cells and kill them from the inside,” said Professor Johann de Bono, a professor at the Institute of Cancer Research. “Our early study shows that it has the potential to treat a large number of different types of cancer, and particularly some of those with very poor survival rates,” de Bono said.

“TV has manageable side effects, and we saw some good responses in the patients in our trial, all of whom had late-stage cancer that had been heavily pre-treated with other drugs and who had run out of other options,” he said.

The researchers have already begun additional trials of the drug in different tumour types and as a second-line treatment for cervical cancer, where response rates were particularly high. They are also developing a test to pick out the patients most likely to respond.


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Health

6 Protein-Rich Foods You Should Eat After A Workout

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What you eat before and after a workout can affect your health, weight loss goals and how you respond to exercise. The right kind of nutrition is important for regular progress and achieve your desired goals on time. However, it is a common tendency to put more attention to what you eat before your workout than what you eat after a workout. In this article, we talk about the right kind of proteins which you must eat after a workout.

Why is it important to eat right after a workout?

On exercising, muscles use glycogen stories for fuel. This makes muscles being slightly deprived of glycogen. Healthline mentions that some proteins in muscles also get broken down. The body tries to rebuild its oxygen stores and eating the right nutrients can help you do this faster. For good recovery, the right kind of nutrition can improve your recovery as well.

 

Proteins to eat after a workout

Exercising results in breakdown of muscle protein. The rate at which this happens depends on the intensity of your exercise. Consuming proteins after a workout can give your body amino acids for repairing rebuilding the lost proteins.

1. Eggs:

Whole eggs can be a good post-workout snack. Packed with protein, eggs while provide you with the right kind of nutrition and will improve your muscle building. People trying to lose weight can also eat eggs after working out.

2. Sweet potato:

While rich in carbs, sweet potato also contains protein. Consuming carb-rich food can refuel you after a session of intense workout.

3. Cottage cheese:

For times you feel too tired to prepare an entire post-workout meal, you can simply slice some cottage cheese into cubes, sprinkle some salt and black pepper on it and eat it raw. Cottage cheese contains good amount of protein that can help you recover after your workout.

4. Quinoa:

Fibre and protein content in quinoa make it an ideal post-workout meal. What’s more is that quinoa is gluten-free and can help people on a weight loss diet as well.

5. Chicken:

Chicken is lean protein that can help you feel energised after a workout. Protein from chicken can help you build muscle mass.

6. Fatty fish like salmon and tuna:

Along with being rich in omega 3 fatty acids, fatty fish like salmon and tuna are also rich sources of protein. Omega 3 fatty acids in fatty fish are good for heart health. Fatty fish is low in carbs and can thus be included in weight loss diet as well.

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Health

Want To Get Rid Of Bloating, Stomach Cramps Once And For All? Cut Down These Foods From Your Diet

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Cutting out specific foods can alleviate gastrointestinal issues for physically active people, especially a runner, researchers say.

The study, conducted by researchers from the Anglia Ruskin University in Britain, showed that a low fermentable oligosaccharide, disaccharide, monosaccharide and polyol (or FODMAP) diet reduces some of the issues caused by exercise such as stomach cramps and bloating, and improves a person’s perceived ability to exercise.

FODMAP foods include those containing lactose (milk, yoghurt and cheese), fructans (found in cereals, breads and pasta), galactic-oligosaccharides (legumes and onions), excess fructose (for example in apples, pears and asparagus) and polyols (often added as a food additive).

 

“We found a clear benefit when following the low FODMAP diet, with a reduction in exercise-related gastrointestinal symptoms amongst otherwise healthy, recreational runners,” said Justin Roberts, Principal Lecturer at the varsity.

For the study, the researchers involved a group of healthy recreational exercisers. Everyone in the group followed two eating plans for one week at a time, with the key difference being the FODMAP content.

The findings, published in the Journal of the International Society of Sports Nutrition, found that 69 per cent of those following a low FODMAP diet experienced an improvement in symptoms and were able to exercise more frequently and at a higher intensity.

In addition, the improvement in perceived pain, in conjunction with reduced experiences of bloating whilst on a low FODMAP diet, is likely explained by a reduction in intestinal water volume and gas production, caused by fewer indigestible carbohydrates available for fermentation in the gut.

However, further studies are needed to examine the benefits of this diet when combined with long-term training strategies. It is important that people take care if deciding to follow a low FODMAP diet, as reductions in total caloric and carbohydrate intake may impact on nutritional quality, Roberts suggested.

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Health

How black coffee can reduce your risk of type 2 diabetes

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The rate at which type 2 diabetes is increasing around the world is really high. It is important to understand what measures can prevent the disease and also which of them can increase your risk of developing it.

Coffee is a very common beverage all around the world, especially in countries that have very cold climatic conditions, timesnownews.com reported.

When the beverage is a staple in so many households, it is important to understand its effect on diabetes — risk and treatment.

 

Does diabetes reduce the risk of developing type 2 diabetes? Does it help in reversing it? Read on to answer all your questions.

A cup of black coffee every day can reduce your risk of developing diabetes

According to a study published by the American Diabetes Association, people who drink coffee have a lower level of blood sugar.

Another study found that the risk of developing diabetes decreased by nine percent in people who drank one cup of coffee every day. One more study that specifically studied women of postmenopausal women found that women who drank six cups of coffee every day had a 22 percent lower risk of diabetes. There happen to be various studies that second this notion, therefore it may be safe to believe that coffee can reduce the risk of developing type 2 diabetes.

How to drink coffee to reduce the risk of type 2 diabetes?

Here is how you should drink your coffee to reduce your risk of developing type 2 diabetes-

? Regular coffee is better to reduce risk than decaffeinated coffee.

? Prefer to not use sweeteners like sugar.

? Avoid drinking coffee with any dairy products like milk or cream.

? Remember coffee has benefits for diabetes only when consumed in its purest form.

? Artificially sweetened coffee may lead to weight gain and increase your risk of diabetes.

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