Connect with us

Health

Coffee compounds may help fight prostate cancer

The Kashmir Monitor

Published

🕒

on

IST

In a first, scientists have identified compounds found in coffee which may inhibit the growth of prostate cancer. The study, published in the journal The Prostate, was carried out on drug-resistant cancer cells in cell culture and in a mouse model. Coffee is a complex mixture of compounds which has been shown to influence human health in both positive and negative ways. There is increasing evidence that drinking certain types of coffee is associated with a reduction in incidence of some cancers, including prostate cancers.
Researchers from Kanazawa University in Japan have studied the effects of two compounds found in coffee, kahweol acetate and cafestol, on prostate cancer cells and in animals, where they were able to inhibit growth in cells which are resistant to common anti-cancer drugs such as Cabazitaxel. The researchers initially tested six compounds, naturally found in coffee, on the proliferation of human prostate cancers cells in a petri-dish. They found that cells treated with kahweol acetate and cafestol grew more slowly than controls. They then tested these compounds on prostate cancer cells which had been transplanted to 16 mice.
Four mice were controls, four were treated with kahweol acetate, four with cafestol, with the remaining mice being treated with a combination of kahweol acetate and cafestol. “We found that kahweol acetate and cafestol inhibited the growth of the cancer cells in mice, but the combination seemed to work synergistically, leading to a significantly slower tumour growth than in untreated mice,” said Hiroaki Iwamoto from Kanazawa University.
“After 11 days, the untreated tumours had grown by around three and a half times the original volume, whereas the tumours in the mice treated with both compounds had grown by around just over one and a half times the original size,” said Iwamoto. This is a pilot study, so this work shows that the use of these compounds is scientifically feasible, but needs further investigation, researchers said. It does not mean that the findings can yet be applied to humans.
“What it does show is that these compounds appear to have an effect on drug resistant cells prostate cancer cells in the right circumstances, and that they too need further investigation,” said Iwamoto. “We are currently considering how we might test these findings in a larger sample, and then in humans,” he said.
Kahweol acetate and cafestol are hydrocarbons, naturally found in Arabica coffee. The coffee-making process has been found to affect whether these compounds remain in coffee after brewing (as with espresso), or whether they are stripped out (as when filtered). “These are promising findings, but they should not make people change their coffee consumption. However, if we can confirm these results, we may have candidates to treat drug-resistant prostate cancer,” said Atsushi Mizokami, professor at Kanazawa University.


The Kashmir Monitor is the fastest growing newspaper as well as digitial platform covering news from all angles.

Advertisement
Loading...
Comments

Health

Common Causes of Neck and Shoulder Pain

The Kashmir Monitor

Published

on

If you have a 9 to 5 job that requires you to sit in front of a computer, chances are you have been bugged by neck and shoulder pain for many times already.The discomfort you feel may range anywhere from mild to severe. Moving the affected area may trigger the pain or cause it to worsen.

Non-steroidal anti-inflammatory drugs or NSAIDs are the most commonly prescribed drugs to those who are suffering from neck and shoulder pain. The problem with the intake of these medications is they yield unfavorable side effects most especially when taken for a long period of time. The application of liniment may also be done, although the topically used product may cause skin irritation in some.

It’s for these reasons why considering a few home remedies for dealing with neck and shoulder pain is a good idea. Some of them include:

 

• Alternating hot and cold compress – Doing this for about 20 minutes several times a day can help get rid of the pain and inflammation in the affected areas. If you have the problem, you may also take a shower using cold and water alternately to attain relief.

• Mobilizing the neck and shoulder – Immobilizing the painful area for a long time may only do more harm than good. That’s why after about 48 hours or when the pain and inflammation have subsided a bit, gently mobilizing the neck and shoulder can help in restoring function as well as flexibility and strength of the muscles in the area.

Neck and shoulder pain can be due to several different reasons. When having the problem, it’s very important to pinpoint the cause so that it may be managed appropriately. Here are the common causes:

• Poor posture. Naturally, it’s very likely for you to suffer from neck and shoulder pain if your posture is not top-notch. No matter if you are standing up, sitting down or lying, proper posture is important in order to have the problem avoided.

• Overuse of the muscles and joints of the neck and shoulders. Repeated movements of the neck and shoulder can cause pain in these areas as the muscles get fatigued and the joints are given more work than they could normally handle.

• A pinched neck or shoulder nerve. When there’s compression of the nerve in the neck or shoulder or too much pressure is applied to it, a condition called pinched nerve may occur. The pain felt also usually runs down on one side of your arm.

• Frozen neck or shoulder. A frozen neck or shoulder usually stems from the lack of movement due to pain and inflammation brought about by an injury. As more and more movement is introduced, the problem gradually goes away.

• Swelling of a tendon in the neck or shoulder area. Medically known as tendonitis, the swelling of a tendon (a band that attaches a muscle to a bone) can cause pain in the neck and shoulder, also causing the said areas to be frozen.

• Inflammation of the bursa. This condition which is also referred to as bursitis is brought about by overuse, trauma, gout, arthritis and infection, thus causing the bursa (sac surrounding the shoulder joint) to get inflamed.

• Whiplash and osteoarthritis. Both whiplash (injury to the neck due to forceful and rapid back-and-forth movement of the neck joint) and osteoarthritis (degeneration of the cartilage of a joint) may also result in neck and shoulder pain.

• Inflammation of the lymph nodes found in the neck. There are instances when pain in the neck and shoulders is brought about by an infection, causing the lymph nodes in the neck to get inflamed and tender.

Continue Reading

Health

How to Remove Uric Acid Crystallization in Joints (Gout and Joint pain)

The Kashmir Monitor

Published

on

Gout and pain in the joints are known conditions that affect a lot people. Some go for supplements and over-the-counter medicine for relief.

What many do not know is that many healthy remedies are available to help in dealing with these conditions. Besides being convenient and effective, natural ways also offer added health benefits to the body.

What you will read next is a great and healthy way to remove uric acid crystallization in joints.

 

Cucumber is one produce you would always want to the grocery for. Making a juice out of it is great at bringing down the temperature of the body. Besides its being a an effective alkalizing agent, it also works well In the removal of the uric acid that has been crystalized in the joints which usually happens in the case of gout.

When drinking this juice, a slight pain might be felt. This is good because this is a sign that healing is taking place. This happens when the old toxins that will be removed are being stirred.

You might want to add want to add ginger and celery. They work well in the reduction of inflammation when the body undergoes a cleansing process.

To prepare this mix you will need the following:

• 2 ribs of celery
• 1 average sized cucumber
• A slice of lemon
• 1 inch young ginger root

Make sure that you have prepared all the necessary ingredients. Clean them well. You may use some vegetable wash or wash them thoroughly.

First, make small cucumber pieces. Slice them in such a way that they will fit into your juicer. Know your juicer’s capacity. Then check the rib of the celery. Make sure that you got rid of the dirt that has accumulated on it. After that, take the lemon and cut it into half. This is all you need. Put the other half in the fridge. Lastly, get the ginger root and carve it out.

Enjoy the drink and deal with the crystalized uric acid. Drink as often as needed.

Continue Reading

Health

Endogamy may up infertility risk in Indian men

Avatar

Published

on

A team of researchers have identified that deletions of the Y chromosomes, responsible for the production of sperms, can cause infertility in Indian men.

The study, published in the journal, ‘Scientific Reports’, illustrates how the ethnicity, endogamy and long-time geographical isolation of Indian populations might have played a major role in the high frequencies of deletion events.

According to the researchers, including K Thangaraj from Centre for Cellular and Molecular Biology, deletions in the A Zoospermia Factor (AZF) regions on the human Y chromosome are reported as one of the most common causes of severe testiculopathy and spermatogenic defects leading to male infertility.

 

For the study, the researchers screened blood samples of 973 infertile men, consisting of 771 azoospermia (complete absence of sperm), 105 oligozoospermia (low sperm count) and 97 oligoteratozoospermia (low sperm count with abnormal shape and size) patients.

The deletion screening was carried out using AZF-specific markers.

The experiments were carried in accordance with the relevant guidelines and regulations approved for research on human samples.

The study revealed deletion events in a total of 29.4 per cent of infertile Indian men. Of these, non-allelic homologous recombination events accounted for 25.8 per cent.

Indian populations are unique in their origin and have been practicing endogamy for the last two thousand years, and therefore it is important to add a study of the frequencies of AZF deletions on the Y chromosome and their association with fertility in Indian idiopathic infertile men to similar studies from other parts of the world, the researchers said.

Continue Reading

Latest News

Subscribe to The Kashmir Monitor via Email

Enter your email address to subscribe to The Kashmir Monitor and receive notifications of new stories by email.

Join 965,820 other subscribers

Archives

April 2019
M T W T F S S
« Mar    
1234567
891011121314
15161718192021
22232425262728
2930  
Advertisement