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Fatty liver can be reduced using a diabetic drug, claims Kashmiri Doc

Mubashir Bukhari

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By Mubashir Bukhari

Srinagar, Mar 27: In a ground-breaking study, a Kashmiri doctor claims to have found a way to reduce liver fat in fatty liver diseases using a Type 2 diabetes drug.
Mohammad Shafi Kuchay, a resident of Humhama here, who earlier worked at SKIMS Soura, is currently holding the position of Consultant Endocrinology and Diabetes at Medanta, Gurgaon.
He along with team of doctors at the hospital have shown promise in the treatment of non-alcoholic fatty liver disease (NAFLD) in the small “E-LIFT study” which they recently presented at “ENDO 2018: The Endocrine Society Annual Meeting” in Chicago.
According to the study conducted by them, empagliflozin drug which was used to treat Type 2 diabetes has the potential to reduce liver fat in patients with non-alcoholic fatty liver disease (NAFLD).
Dr Kuchay said that for the first time in the world such a research has been carried in the drug and they received good response from the Endocrine society.
“Our research was adjudged as the best and we received lot of approbation at the Endocrine meet in Chicago,” he said.
Dr Kuchay, who is also the principal investigator of the study, told The Kashmir Monitor that till now, there was no medicine available in the market for fatty liver.
“Despite the fact that nonalcoholic steatohepatitis (NASH) may progress to cirrhosis of the liver and liver cancer, there are no approved medications for treating NAFLD or NASH,” he said. “Our results suggest that empagliflozin may help in treating NAFLD.”
“Not only this drug helps in diabetes but we found it can help in reducing fatty liver in patients. We demonstrated its second function first time to the world,” he said.
He said previous studies had established the potential of the diabetes drug empagliflozin in decreasing liver fat in rodents.
“I thought let us try this on humans. First step was to register it and then in 2016 we started research on this drug,” Dr Kuchay said.
He said in the trial, the team included patients who were 40 years or older and had Type 2 diabetes and NAFLD.
He said at the beginning of the study and 20 weeks later, the patients underwent measurement of their liver fat using a new technique called magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF), which is an accurate and robust technique for liver fat estimation.
The patients also had blood tests of their liver enzyme levels and other biochemical parameters.
“After 20 weeks of treatment, the liver fat of patients receiving empagliflozin decreased from an average of 16.2 to 11.3 per cent, whereas the control group had only a decrease from 16.4 to 15.6 percent, a statistically significant difference between groups,” Dr Kuchay said.
“Overall, 25% of the control group had an increase in liver fat during the study period, half had no change, and 25% had a reduction. In the empagliflozin group, no patients had increased liver fat, 23% remained stable, and 77% experienced a decrease in liver fat.”
He said that the initial results are promising and open up the possibility that empagliflozin may provide additional benefits for patients with diabetes.
His study got much attention in the international media and was published by numerous newspapers and scientific journals worldwide.
Dr Kuchay was also invited by Medscape, a well-known professional medical website, for video CME presentation, along with Professor Silvio Inzucchi (USA), a renowned name in the field of diabetes research.

 

Mubashir joined The Kashmir Monitor as a reporter/ sub-editor in Jan 2013. Since then, he has been consistently covering beats including conflict, politics, education, and health. He is also handling online section of the paper besides working as Video Producer.

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Guv reassigns depts to Advisors

Monitor News Bureau

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Srinagar, Jul 17: Governor Satya Pal Malik Wednesday re-assigned the charge of departments to his Advisors.

As per the order issued by the General Administration Department (GAD), Advisor Vijay Kumar has been assigned charge of the departments of Home, Forest, Ecology & Environment, Health & Medical Education, Youth Services & Sports, Hospitality & Protocol, Civil Aviation, Estates and Information.

Advisor Khurshid A Ganai has been assigned the charge of the departments of Food, Civil Supplies & Consumer Affairs, ARI & Trainings, Cooperative, Floriculture, Tourism, Election, Planning, Development & Monitoring, Labour & Employment and Higher Education.

 

Advisor, K Skandan has been assigned the charge of the departments of Information Technology, Industries and Commerce, Animal & Sheep Husbandry, Ladakh Affairs, Revenue, Disaster Management, Relief, Rehabilitation & Reconstruction, Transport and Law, Justice & Parliamentary Affairs.

Advisor Kewal Kumar Sharma has been assigned the charge of the departments of Public Works (R&B), Public Health Engineering, Irrigation and Flood Control, Power, Finance, Housing & Urban Development and Science and Technology.

Advisor Farooq Ahmad Khan has been assigned the charge of the departments of School Education, Technical Education, Hajj and Auqaf, Social Welfare, Tribal Affairs, Culture, Agriculture/ Horticulture and Rural Development & Panchayati Raj.

Papers related to General Administration Department shall be submitted by the Chief Secretary directly to Governor.

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PDP still believes it will bounce back

Monitor News Bureau

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Srinagar, Jul 17: A high level meeting of the Peoples Democratic Party’s (PDP) leadership from south Kashmir was held at the party head office here in which various crucial issues confronting the state at present were discussed in detail.

Chaired by Party Vice President Abdul Rahman Veeri, the meeting deliberated over various measures that the party has taken in the recent past to widen its reach and make masses aware about its agenda and mission.

Veeri in his address stressed upon the leadership to hold constant contact with the general public and highlight the issues they face on day to day basis and seek their resolution on priority from the concerned quarters.

 

“Veeri expressed full confidence that the PDP will bounce back in a revitalised form on the state’s political scene and that the party will continue to push for peace with dignity which is the focal point of its agenda,” the party statement read.

He, it added, said that the workers are committed to the agenda of the party and the vision provided by its founder Mufti Sayeed who founded the party in “trying circumstances”.

PDP General Secretary Ghulam Nabi Lone Hanjura, while addressing the meeting, stated that the party “will continue to pursue it till durable peace is restored and that will never barter interests of the state against petty political gains.”

PDP leader, Sartaj Madni in his address stated that the need of the hour is that the party leadership, functionaries, activists and supporters must work in close coordination and make sustainable efforts in party’s overall growth and impressive performance in the coming time.

The participants of the meeting expressed full confidence in the leadership of the PDP President Mehbooba Mufti, resolving in unison to support her each and every endeavour aimed at getting the people out of the cycle of uncertainty and lead the state towards a prosperous future.

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Will find, deport all infiltrators in India: HM

Press Trust of India

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New Delhi, Jul 17:  The Centre will identify illegal immigrants staying in any part of the country and deport them as per international law, Home Minister Amit Shah said in Rajya Sabha on Wednesday.

The minister was replying to a supplementary query by Samajwadi Party member Javed Ali Khan on whether the National Register of Citizens will be implemented in other states as well.

Currently, the NRC is being updated under the strict monitoring of the Supreme Court in Assam and July 31 has been set as a deadline for final publication of the registered data.

 

“It is a very good question. The NRC is part of the Assam Accord and was also in (BJP’s) election manifesto based on which the government has come to power. The government will identify illegal immigrants living on every inch of the country’s soil and will deport them as per the international law,” Shah said in the Upper House.

Noting that the Centre has received many representations for extending the NRC deadline in Assam, Minister of State for Home Affairs Nityanand Rai said a petition signed by about 25 lakh applicants submitted to the Centre and the President demanded extension to correct anomalies.

Since many genuine names have been left out and many bogus names are registered, the minister said, “So the government has requested the (Supreme) Court to extend the time for this purpose”.

“There will be some delay but the NRC will be implemented properly without any faults,” he said, asserting that the government’s intention is to ensure no genuine citizen is left out of the NRC.

To a query on number of Rohingya Muslims in India, Rai said, “We don’t have an accurate data. They are spread across the country. Some of them have gone back to Bangladesh. We will get the data soon.” The government’s intention is to ensure no illegal immigrant is registered under the NRC. Foreigner tribunals have also been set up to curb illegal stay of foreigners in India, he added.

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